Assay Detail
Binding
CHEMBL697426
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Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL1918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.23 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301536 | — | — | 1 | 7.83 |
| CHEMBL51660 | — | — | 1 | 7.49 |
| CHEMBL52295 | — | — | 1 | 7.22 |
| CHEMBL50041 | — | — | 1 | 7.09 |
| CHEMBL52742 | — | — | 1 | 7.07 |
| CHEMBL298800 | — | — | 1 | 7.03 |
| CHEMBL297919 | — | — | 1 | 6.82 |
| CHEMBL299291 | — | — | 1 | 6.82 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 6.75 |
| CHEMBL299365 | — | — | 1 | 6.65 |
| CHEMBL51395 | — | — | 1 | 6.63 |
| CHEMBL51008 | — | — | 1 | 6.62 |
| CHEMBL38499 | — | — | 1 | 6.57 |
| CHEMBL51054 | — | — | 1 | 6.33 |
| CHEMBL300928 | — | — | 1 | 6.29 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.15 |
| CHEMBL52514 | — | — | 1 | 5.66 |
| CHEMBL54291 | — | — | 1 | 5.44 |
| CHEMBL54238 | — | — | 1 | 5.29 |
| CHEMBL53702 | — | — | 1 | 5.22 |
| CHEMBL298779 | — | — | 1 | 4.86 |
| CHEMBL53775 | — | — | 1 | 4.77 |
| CHEMBL53194 | — | — | 1 | 4.54 |
| CHEMBL297283 | — | — | 1 | 4.38 |
| CHEMBL54073 | — | — | 1 | - |
| CHEMBL53655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301536 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL51660 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL52295 | — | Ki | = | 60.5 | nM | 7.22 |
| CHEMBL50041 | — | Ki | = | 80.4 | nM | 7.09 |
| CHEMBL52742 | — | Ki | = | 85.7 | nM | 7.07 |
| CHEMBL298800 | — | Ki | = | 93.6 | nM | 7.03 |
| CHEMBL297919 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL299291 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL275040 | KAINIC ACID | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL299365 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL51395 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL51008 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL38499 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL51054 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL300928 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL52514 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL54291 | — | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL54238 | — | Ki | = | 5130.0 | nM | 5.29 |
| CHEMBL53702 | — | Ki | = | 6060.0 | nM | 5.22 |
| CHEMBL298779 | — | Ki | = | 13900.0 | nM | 4.86 |
| CHEMBL53775 | — | Ki | = | 17100.0 | nM | 4.77 |
| CHEMBL53194 | — | Ki | = | 29100.0 | nM | 4.54 |
| CHEMBL297283 | — | Ki | = | 41200.0 | nM | 4.38 |
| CHEMBL54073 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL53655 | — | Ki | > | 1000.0 | nM | - |