Compound Detail
CHEMBL51008
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Basic Information
| ChEMBL ID | CHEMBL51008 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WGIDMAYAWXETPY-QMMMGPOBSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
215.2
MW (Da)
0.99
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL1918 | Ki | 6.62 | 6.62 | 241.0 | 1 |
| Glutamate receptor 4 CHEMBL3190 | Ki | 5.33 | 5.33 | 4710.0 | 1 |
| Glutamate receptor ionotropic, kainate 3 CHEMBL3684 | Ki | 4.91 | 4.91 | 12400.0 | 1 |
| Glutamate receptor ionotropic, kainate 5 CHEMBL2675 | Ki | 4.67 | 4.67 | 21400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 241.0 | nM | 6.62 | Binding affinity of compound was determined against Ionotropic glutamate recepto... | 10969973 |
| Glutamate receptor 4 | Ki | = | 4710.0 | nM | 5.33 | Binding affinity of compound was determined against Ionotropic glutamate recepto... | 10969973 |
| Glutamate receptor ionotropic, kainate 3 | Ki | = | 12400.0 | nM | 4.91 | Binding affinity of compound was determined against Ionotropic glutamate recepto... | 10969973 |
| Glutamate receptor ionotropic, kainate 5 | Ki | = | 21400.0 | nM | 4.67 | Binding affinity of compound was determined against Glutamate receptor (KA2) usi... | 10969973 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor ionotropic, kainate 1 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor ionotropic, kainate 2 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Unchecked | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor 1 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor 2 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor 4 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor ionotropic, kainate 5 | 1 |
| 10969973 | 10.1016/s0960-894x(00)00346-2 | Glutamate receptor ionotropic, kainate 3 | 1 |
Data from ChEMBL 36 via Core Engine