Assay Detail
Binding
CHEMBL874133
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Binding affinity of compound was determined against Glutamate receptor (KA2) using cell membranes prepared from HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 5 (CHEMBL2675) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.39 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 7.10 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.12 |
| CHEMBL51660 | — | — | 1 | 5.00 |
| CHEMBL51008 | — | — | 1 | 4.67 |
| CHEMBL298800 | — | — | 1 | 4.08 |
| CHEMBL301536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL51660 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL51008 | — | Ki | = | 21400.0 | nM | 4.67 |
| CHEMBL298800 | — | Ki | = | 82200.0 | nM | 4.08 |
| CHEMBL301536 | — | Ki | > | 10000.0 | nM | - |