Assay Detail
Functional
CHEMBL697515
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Effective concentration for MIPA (muscarinic-stimulated inositol phosphate accumulation) activity in SK-N-SH neuroblastoma cells expressing human muscarinic M3 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-SH |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.97 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315676 | — | — | 1 | 5.08 |
| CHEMBL354738 | — | — | 1 | 5.06 |
| CHEMBL352908 | — | — | 1 | 5.05 |
| CHEMBL168545 | — | — | 1 | 5.02 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.97 |
| CHEMBL85678 | — | — | 1 | 4.84 |
| CHEMBL313918 | — | — | 1 | 4.79 |
| CHEMBL314737 | OXADIAZOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315676 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL354738 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL352908 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL168545 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL14 | CARBACHOL | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL85678 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL313918 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL314737 | OXADIAZOLE | EC50 | = | 104000.0 | nM | - |