Compound Detail
CHEMBL314737
OXADIAZOLE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL314737 |
| Name | OXADIAZOLE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XARSDFQMNNNPBL-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
180.2
MW (Da)
0.07
ALogP
5
HBA
1
HBD
68.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.52
EC50 2 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor CHEMBL1907609 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Muscarinic receptor M1 and M2 CHEMBL2111433 | IC50 | 7.06 | 7.06 | 88.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Muscarinic acetylcholine receptor M1 CHEMBL216 | EC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor | IC50 | = | 0.3 | nM | 9.52 | Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to labe... | - |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 20.0 | nM | 7.7 | Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H... | - |
| Muscarinic receptor M1 and M2 | IC50 | = | 88.0 | nM | 7.06 | Compound was evaluated for its inhibition of [3H]quinuclidinyl benzilate binding... | - |
| Muscarinic acetylcholine receptor M1 | IC50 | = | 400.0 | nM | 6.4 | Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H... | - |
| Muscarinic acetylcholine receptor M1 | EC50 | = | 100000.0 | nM | 4.0 | Effective concentration for HMPA (human muscarinic inositol phosphate accumulati... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1732546 | 10.1021/jm00080a014 | Muscarinic acetylcholine receptor | 6 |
| 2213823 | 10.1021/jm00172a003 | Muscarinic acetylcholine receptor | 6 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic acetylcholine receptor M1 | 3 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic acetylcholine receptor M3 | 2 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic acetylcholine receptors; M1 & M2 | 2 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic acetylcholine receptor | 1 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic receptor M1 and M2 | 1 |
| - | 10.1016/S0960-894X(00)80538-7 | Muscarinic acetylcholine receptor M2 | 1 |
Data from ChEMBL 36 via Core Engine