Assay Detail
Functional
CHEMBL749008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.32 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | — | 1 | 7.70 |
| CHEMBL315676 | — | — | 1 | 5.98 |
| CHEMBL354259 | — | — | 1 | 5.79 |
| CHEMBL354738 | — | — | 1 | 5.77 |
| CHEMBL83074 | — | — | 1 | 5.66 |
| CHEMBL313918 | — | — | 1 | 5.55 |
| CHEMBL166423 | — | — | 1 | 5.50 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.46 |
| CHEMBL167438 | — | — | 1 | 5.40 |
| CHEMBL166593 | — | — | 1 | 5.35 |
| CHEMBL168561 | — | — | 1 | 5.29 |
| CHEMBL166537 | — | — | 1 | 5.28 |
| CHEMBL85678 | — | — | 1 | 5.10 |
| CHEMBL168545 | — | — | 1 | 5.07 |
| CHEMBL168639 | — | — | 1 | 5.01 |
| CHEMBL74300 | — | — | 1 | 4.89 |
| CHEMBL352832 | — | — | 1 | 4.81 |
| CHEMBL169011 | — | — | 1 | 4.80 |
| CHEMBL84893 | — | — | 1 | 4.59 |
| CHEMBL312823 | — | — | 1 | 4.52 |
| CHEMBL168991 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL315676 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL354259 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL354738 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL83074 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL313918 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL166423 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL14 | CARBACHOL | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL167438 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL166593 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL168561 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL166537 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL85678 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL168545 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL168639 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL74300 | — | IC50 | = | 12930.0 | nM | 4.89 |
| CHEMBL352832 | — | IC50 | = | 15590.0 | nM | 4.81 |
| CHEMBL169011 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL84893 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL312823 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL168991 | — | IC50 | = | 59300.0 | nM | 4.23 |