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Compound Detail

CHEMBL352832

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C#CCCO/N=C1\CN2CCC1C2

Basic Information

ChEMBL ID CHEMBL352832
Phase Preclinical
Structure Type MOL
InChI Key IYTIRJKFPPCZDQ-ZHACJKMWSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

178.2
MW (Da)
0.72
ALogP
3
HBA
0
HBD
24.8
PSA (Ų)
0.36
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H14N2O
MW 178.23
Aromatic Rings 0
Heavy Atoms 13
NP-Likeness -0.22

Activity Summary

IC50 4 meas. best 7.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.08 7.08 83.0 1
Muscarinic receptor M1 and M2
CHEMBL2111433
IC50 5.01 5.01 9806.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 4.84 4.84 14450.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
IC50 4.81 4.81 15590.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptors; M1 & M2 2
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic receptor M1 and M2 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor M2 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine