Assay Detail
Binding
CHEMBL748171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of [3H]cis-methyldioxolane binding to label agonist sites (RCMD) in rat neocortex
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Neocortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.65 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | — | 1 | 9.52 |
| CHEMBL315676 | — | — | 1 | 8.46 |
| CHEMBL168545 | — | — | 1 | 8.44 |
| CHEMBL354738 | — | — | 1 | 8.40 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 8.17 |
| CHEMBL83074 | — | — | 1 | 8.10 |
| CHEMBL352908 | — | — | 1 | 7.90 |
| CHEMBL85678 | — | — | 1 | 7.74 |
| CHEMBL313918 | — | — | 1 | 7.66 |
| CHEMBL74300 | — | — | 1 | 7.60 |
| CHEMBL169011 | — | — | 1 | 7.50 |
| CHEMBL166537 | — | — | 1 | 7.46 |
| CHEMBL312823 | — | — | 1 | 7.46 |
| CHEMBL168561 | — | — | 1 | 7.41 |
| CHEMBL168639 | — | — | 1 | 7.36 |
| CHEMBL166423 | — | — | 1 | 7.34 |
| CHEMBL84893 | — | — | 1 | 7.34 |
| CHEMBL166782 | — | — | 1 | 7.32 |
| CHEMBL168991 | — | — | 1 | 7.26 |
| CHEMBL352832 | — | — | 1 | 7.08 |
| CHEMBL354259 | — | — | 1 | 7.06 |
| CHEMBL166593 | — | — | 1 | 7.04 |
| CHEMBL167015 | — | — | 1 | 6.96 |
| CHEMBL167438 | — | — | 1 | 6.92 |
| CHEMBL170903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL315676 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL168545 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL354738 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL14 | CARBACHOL | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL83074 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL352908 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL85678 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL313918 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL74300 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL169011 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL166537 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL312823 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL168561 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL168639 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL166423 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL84893 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL166782 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL168991 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL352832 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL354259 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL166593 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL167015 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL167438 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL170903 | — | IC50 | > | 100.0 | nM | - |