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Compound Detail

CHEMBL168991

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COCC#CCO/N=C1\CN2CCC1C2

Basic Information

ChEMBL ID CHEMBL168991
Phase Preclinical
Structure Type MOL
InChI Key ANTVCMHSNDCZOH-VAWYXSNFSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

208.3
MW (Da)
0.34
ALogP
4
HBA
0
HBD
34.1
PSA (Ų)
0.38
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H16N2O2
MW 208.26
Aromatic Rings 0
Heavy Atoms 15
NP-Likeness 0.02

Activity Summary

IC50 4 meas. best 7.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 7.26 7.26 55.0 1
Muscarinic receptor M1 and M2
CHEMBL2111433
IC50 4.45 4.45 35434.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 4.37 4.37 42400.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
IC50 4.23 4.23 59300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptors; M1 & M2 2
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic receptor M1 and M2 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor M2 1
- 10.1016/S0960-894X(00)80538-7 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine