Assay Detail
Functional
CHEMBL744240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human Muscarinic acetylcholine receptor M1 using [3H]quinuclidinyl benzilate to label antagonist site (RQNB) in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.23 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | — | 1 | 6.40 |
| CHEMBL354259 | — | — | 1 | 5.96 |
| CHEMBL83074 | — | — | 1 | 5.69 |
| CHEMBL166423 | — | — | 1 | 5.58 |
| CHEMBL166537 | — | — | 1 | 5.43 |
| CHEMBL167438 | — | — | 1 | 5.43 |
| CHEMBL166593 | — | — | 1 | 5.42 |
| CHEMBL74300 | — | — | 1 | 5.40 |
| CHEMBL168545 | — | — | 1 | 5.31 |
| CHEMBL84893 | — | — | 1 | 5.27 |
| CHEMBL168561 | — | — | 1 | 5.25 |
| CHEMBL354738 | — | — | 1 | 5.24 |
| CHEMBL168639 | — | — | 1 | 5.10 |
| CHEMBL169011 | — | — | 1 | 5.03 |
| CHEMBL315676 | — | — | 1 | 5.02 |
| CHEMBL166782 | — | — | 1 | 5.02 |
| CHEMBL313918 | — | — | 1 | 5.00 |
| CHEMBL312823 | — | — | 1 | 4.90 |
| CHEMBL352832 | — | — | 1 | 4.84 |
| CHEMBL168991 | — | — | 1 | 4.37 |
| CHEMBL85678 | — | — | 1 | 4.07 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314737 | OXADIAZOLE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL354259 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL83074 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL166423 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL166537 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL167438 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL166593 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL74300 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL168545 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL84893 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL168561 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL354738 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL168639 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL169011 | — | IC50 | = | 9440.0 | nM | 5.03 |
| CHEMBL315676 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL166782 | — | IC50 | = | 9640.0 | nM | 5.02 |
| CHEMBL313918 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL312823 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL352832 | — | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL168991 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL85678 | — | IC50 | = | 85050.0 | nM | 4.07 |
| CHEMBL14 | CARBACHOL | IC50 | = | 124830.0 | nM | - |