Assay Detail
Binding
CHEMBL748212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its inhibition of [3H]quinuclidinyl benzilate binding to label antagonist site (RQNB) in rat neocortex
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Neocortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Muscarinic receptor M1 and M2 (CHEMBL2111433) ↗| Type | SELECTIVITY GROUP |
| Organism | Rattus norvegicus |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.42 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL167438 | — | — | 1 | 7.50 |
| CHEMBL314737 | OXADIAZOLE | — | 1 | 7.06 |
| CHEMBL83074 | — | — | 1 | 6.02 |
| CHEMBL354259 | — | — | 1 | 5.94 |
| CHEMBL166423 | — | — | 1 | 5.69 |
| CHEMBL168561 | — | — | 1 | 5.54 |
| CHEMBL352908 | — | — | 1 | 5.51 |
| CHEMBL166593 | — | — | 1 | 5.45 |
| CHEMBL167015 | — | — | 1 | 5.44 |
| CHEMBL166537 | — | — | 1 | 5.40 |
| CHEMBL354738 | — | — | 1 | 5.38 |
| CHEMBL315676 | — | — | 1 | 5.36 |
| CHEMBL84893 | — | — | 1 | 5.30 |
| CHEMBL74300 | — | — | 1 | 5.28 |
| CHEMBL168639 | — | — | 1 | 5.22 |
| CHEMBL168545 | — | — | 1 | 5.22 |
| CHEMBL169011 | — | — | 1 | 5.14 |
| CHEMBL166782 | — | — | 1 | 5.06 |
| CHEMBL313918 | — | — | 1 | 5.05 |
| CHEMBL352832 | — | — | 1 | 5.01 |
| CHEMBL312823 | — | — | 1 | 4.86 |
| CHEMBL85678 | — | — | 1 | 4.61 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.48 |
| CHEMBL168991 | — | — | 1 | 4.45 |
| CHEMBL170903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL167438 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL314737 | OXADIAZOLE | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL83074 | — | IC50 | = | 958.0 | nM | 6.02 |
| CHEMBL354259 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL166423 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL168561 | — | IC50 | = | 2914.0 | nM | 5.54 |
| CHEMBL352908 | — | IC50 | = | 3112.0 | nM | 5.51 |
| CHEMBL166593 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL167015 | — | IC50 | = | 3655.0 | nM | 5.44 |
| CHEMBL166537 | — | IC50 | = | 3984.0 | nM | 5.40 |
| CHEMBL354738 | — | IC50 | = | 4214.0 | nM | 5.38 |
| CHEMBL315676 | — | IC50 | = | 4359.0 | nM | 5.36 |
| CHEMBL84893 | — | IC50 | = | 5012.0 | nM | 5.30 |
| CHEMBL74300 | — | IC50 | = | 5304.0 | nM | 5.28 |
| CHEMBL168639 | — | IC50 | = | 6045.0 | nM | 5.22 |
| CHEMBL168545 | — | IC50 | = | 5976.0 | nM | 5.22 |
| CHEMBL169011 | — | IC50 | = | 7313.0 | nM | 5.14 |
| CHEMBL166782 | — | IC50 | = | 8689.0 | nM | 5.06 |
| CHEMBL313918 | — | IC50 | = | 8834.0 | nM | 5.05 |
| CHEMBL352832 | — | IC50 | = | 9806.0 | nM | 5.01 |
| CHEMBL312823 | — | IC50 | = | 13850.0 | nM | 4.86 |
| CHEMBL85678 | — | IC50 | = | 24558.0 | nM | 4.61 |
| CHEMBL14 | CARBACHOL | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL168991 | — | IC50 | = | 35434.0 | nM | 4.45 |
| CHEMBL170903 | — | IC50 | > | 1000.0 | nM | - |