Assay Detail
Functional
CHEMBL744230
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Effective concentration for HMPA (human muscarinic inositol phosphate accumulation) activity measured in CHO cells expressing Muscarinic acetylcholine receptor M1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A rationale for the design and synthesis of m1 selective muscarinic agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.24 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315676 | — | — | 1 | 6.05 |
| CHEMBL354738 | — | — | 1 | 5.72 |
| CHEMBL84893 | — | — | 1 | 5.48 |
| CHEMBL74300 | — | — | 1 | 5.46 |
| CHEMBL313918 | — | — | 1 | 5.33 |
| CHEMBL168561 | — | — | 1 | 5.30 |
| CHEMBL83074 | — | — | 1 | 5.29 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.25 |
| CHEMBL168545 | — | — | 1 | 5.23 |
| CHEMBL167438 | — | — | 1 | 4.57 |
| CHEMBL314737 | OXADIAZOLE | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315676 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL354738 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL84893 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL74300 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL313918 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL168561 | — | EC50 | = | 5050.0 | nM | 5.30 |
| CHEMBL83074 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL14 | CARBACHOL | EC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL168545 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL167438 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL314737 | OXADIAZOLE | EC50 | = | 100000.0 | nM | 4.00 |