Assay Detail
Binding
CHEMBL697798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of Specific DL-[H]Ionotropic glutamate receptor AMPA binding to rat brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.88 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 6.22 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 6.10 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.89 |
| CHEMBL14815 | — | — | 1 | 5.32 |
| CHEMBL76232 | D-GLUTAMATE | — | 1 | - |
| CHEMBL174022 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL14815 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL76232 | D-GLUTAMATE | IC50 | ~ | 100000.0 | nM | - |
| CHEMBL174022 | — | IC50 | > | 100000.0 | nM | - |