Compound Detail
CHEMBL14815
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL14815 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUDAMDVQRQNNHZ-RXMQYKEDSA-N |
2
Targets
6
Activities
2
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
186.2
MW (Da)
-0.36
ALogP
5
HBA
3
HBD
109.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.32
EC50 2 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.32 | 4.52 | 4800.0 | 3 |
| Rattus norvegicus CHEMBL376 | IC50 | 5.32 | 5.32 | 4800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 4800.0 | nM | 5.32 | Inhibition of [3H]AMPA binding in rat brain membrane was evaluated | 2859375 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 4800.0 | nM | 5.32 | Tested for inhibition of Specific DL-[H]Ionotropic glutamate receptor AMPA bindi... | 6133955 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 76000.0 | nM | 4.12 | The compound was evaluated for agonist to competitive inhibition of radioligand ... | 8759641 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 76000.0 | nM | 4.12 | Tested for the inhibitory activity of against Ionotropic glutamate receptor AMPA... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8759641 | 10.1021/jm9602569 | Glutamate NMDA receptor | 2 |
| 8759641 | 10.1021/jm9602569 | Glutamate receptor ionotropic, AMPA | 2 |
| 2859375 | 10.1021/jm50001a022 | Rattus norvegicus | 2 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 1 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 2 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 4 | 1 |
| 8759641 | 10.1021/jm9602569 | Metabotropic glutamate receptor 6 | 1 |
| 8759641 | 10.1021/jm9602569 | Glutamate receptor ionotropic, kainate | 1 |
| 2859375 | 10.1021/jm50001a022 | Unchecked | 1 |
| - | 10.1016/S0960-894X(00)80102-X | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(00)80102-X | Rattus norvegicus | 1 |
| 6133955 | 10.1021/jm00360a021 | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine