Assay Detail
Binding
CHEMBL697886
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Binding affinity for Ionotropic glutamate receptor AMPA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.53 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433424 | — | — | 1 | 8.40 |
| CHEMBL24980 | — | — | 1 | 7.75 |
| CHEMBL93287 | — | — | 1 | 7.05 |
| CHEMBL222519 | NBQX | — | 1 | 6.85 |
| CHEMBL277281 | — | — | 1 | 6.82 |
| CHEMBL13260 | YM-90K | — | 1 | 6.46 |
| CHEMBL418952 | — | — | 1 | 6.35 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 6.22 |
| CHEMBL93902 | — | — | 1 | 6.21 |
| CHEMBL329639 | — | — | 1 | 6.21 |
| CHEMBL279116 | — | — | 1 | 6.12 |
| CHEMBL329778 | — | — | 1 | 5.46 |
| CHEMBL91509 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433424 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL24980 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL93287 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL222519 | NBQX | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL277281 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL13260 | YM-90K | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL418952 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL93902 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL329639 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL279116 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL329778 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL91509 | — | IC50 | = | 10000.0 | nM | 5.00 |