Compound Detail
CHEMBL329639
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL329639 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMGKNMJESPOXJS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
325.3
MW (Da)
1.33
ALogP
6
HBA
3
HBD
125.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.67 | 6.44 | 214.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 214.0 | nM | 6.67 | Antagonistic activity against Ionotropic glutamate receptor AMPA using kainate-e... | 11133083 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 611.0 | nM | 6.21 | Binding affinity for Ionotropic glutamate receptor AMPA | 11133083 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Glutamate receptor ionotropic, AMPA | 2 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Glutamate NMDA receptor | 1 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine