Assay Detail
Functional
CHEMBL699741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Ionotropic glutamate receptor AMPA using kainate-evoked current in Xenopus oocytes injected with rat brain mRNA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.74 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24980 | — | — | 1 | 8.30 |
| CHEMBL433424 | — | — | 1 | 7.64 |
| CHEMBL277281 | — | — | 1 | 7.54 |
| CHEMBL222519 | NBQX | — | 1 | 7.51 |
| CHEMBL418952 | — | — | 1 | 7.28 |
| CHEMBL93287 | — | — | 1 | 6.98 |
| CHEMBL329639 | — | — | 1 | 6.67 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 6.64 |
| CHEMBL13260 | YM-90K | — | 1 | 6.58 |
| CHEMBL279116 | — | — | 1 | 5.75 |
| CHEMBL93902 | — | — | 1 | 5.70 |
| CHEMBL91509 | — | — | 1 | 5.58 |
| CHEMBL329778 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24980 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL433424 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL277281 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL222519 | NBQX | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL418952 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL93287 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL329639 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL13260 | YM-90K | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL279116 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL93902 | — | IC50 | = | 2008.0 | nM | 5.70 |
| CHEMBL91509 | — | IC50 | = | 2644.0 | nM | 5.58 |
| CHEMBL329778 | — | IC50 | = | 3252.0 | nM | 5.49 |