Compound Detail
CHEMBL24980
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Basic Information
| ChEMBL ID | CHEMBL24980 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KGABLDAFOWCUMF-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
325.3
MW (Da)
1.33
ALogP
6
HBA
3
HBD
125.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 8.4 | 8.05 | 4.0 | 4 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.14 | 5.14 | 7200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 4.0 | nM | 8.4 | Binding affinity against Ionotropic glutamate receptor AMPA in rat brain | 11133083 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 5.0 | nM | 8.3 | Antagonistic activity against Ionotropic glutamate receptor AMPA using kainate-e... | 11133083 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 18.0 | nM | 7.75 | Affinity towards Ionotropic glutamate receptor AMPA using [3H]AMPA as ligand on ... | 11206442 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 18.0 | nM | 7.75 | Binding affinity for Ionotropic glutamate receptor AMPA | 11133083 |
| Glutamate NMDA receptor | IC50 | = | 7200.0 | nM | 5.14 | In vitro binding affinity towards NMDA glutamate receptor using [3H]5,7-dichloro... | 11206442 |
| Glutamate NMDA receptor | IC50 | = | 7200.0 | nM | 5.14 | Binding affinity for N-methyl-D-aspartate glutamate receptor | 11133083 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Mus musculus | 9 |
| 11206442 | 10.1016/s0960-894x(00)00592-8 | Mus musculus | 3 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Glutamate receptor ionotropic, AMPA | 3 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Rattus norvegicus | 3 |
| 11206442 | 10.1016/s0960-894x(00)00592-8 | Glutamate receptor ionotropic, AMPA | 1 |
| 11206442 | 10.1016/s0960-894x(00)00592-8 | Glutamate NMDA receptor | 1 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Glutamate NMDA receptor | 1 |
| 11133083 | 10.1016/s0960-894x(00)00561-8 | Glutamate receptor ionotropic AMPA | 1 |
Data from ChEMBL 36 via Core Engine