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Assay Detail

CHEMBL698062

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against Normal human diploid cells (human foreskin fibroblasts cells)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Fibroblast
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
Gupta PK, Nassiri MR, Coleman LA, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1989) 32 : 1420 -1425
PubMed 2500527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.00 4.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30286 1 4.00
CHEMBL30711 1 -
CHEMBL33236 1 -
CHEMBL34633 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL34163 1 -
CHEMBL33623 1 -
CHEMBL33064 1 -
CHEMBL30506 1 -
CHEMBL287172 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30286 IC50 = 100000.0 nM 4.00
CHEMBL30711 IC50 > 100000.0 nM -
CHEMBL33236 IC50 > 100000.0 nM -
CHEMBL34633 IC50 > 100000.0 nM -
CHEMBL182 GANCICLOVIR IC50 > 100000.0 nM -
CHEMBL34163 IC50 > 320000.0 nM -
CHEMBL33623 IC50 > 320000.0 nM -
CHEMBL33064 IC50 > 100000.0 nM -
CHEMBL30506 IC50 > 100000.0 nM -
CHEMBL287172 IC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR IC50 > 100000.0 nM -