Assay Detail
Functional
CHEMBL698334
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Inhibitory concentration required to reduce human Jurkat leukemia (JLC sensitive, wild type) cell number to 50% of control cultures
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.34 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293133 | — | — | 1 | 8.38 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.02 |
| CHEMBL57636 | — | — | 1 | 7.58 |
| CHEMBL37656 | — | — | 1 | 7.57 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.43 |
| CHEMBL29602 | — | — | 1 | 7.34 |
| CHEMBL56830 | — | — | 1 | 7.12 |
| CHEMBL57085 | — | — | 1 | 6.99 |
| CHEMBL292177 | — | — | 1 | 6.96 |
| CHEMBL58041 | — | — | 1 | 6.86 |
| CHEMBL294417 | — | — | 1 | 6.67 |
| CHEMBL60807 | — | — | 1 | 6.62 |
| CHEMBL57862 | — | — | 1 | 6.40 |
| CHEMBL60684 | — | — | 1 | 6.37 |
| CHEMBL57685 | — | — | 1 | 6.36 |
| CHEMBL56111 | — | — | 1 | 6.35 |
| CHEMBL57271 | — | — | 1 | 6.34 |
| CHEMBL56149 | — | — | 1 | 6.29 |
| CHEMBL9940 | — | — | 1 | 6.24 |
| CHEMBL417771 | — | — | 1 | 6.24 |
| CHEMBL56144 | — | — | 1 | 6.20 |
| CHEMBL57949 | — | — | 1 | 6.12 |
| CHEMBL292902 | — | — | 1 | 6.12 |
| CHEMBL291690 | — | — | 1 | 6.04 |
| CHEMBL418275 | — | — | 1 | 5.97 |
| CHEMBL56174 | — | — | 1 | 5.95 |
| CHEMBL60818 | — | — | 1 | 5.87 |
| CHEMBL57048 | — | — | 1 | 5.87 |
| CHEMBL291980 | — | — | 1 | 5.85 |
| CHEMBL60920 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293133 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL57636 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL37656 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL43 | AMSACRINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL29602 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL56830 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL57085 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL292177 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL58041 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL294417 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL60807 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL57862 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL60684 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL57685 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL56111 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL57271 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL56149 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL417771 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL9940 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL56144 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL57949 | — | IC50 | = | 753.0 | nM | 6.12 |
| CHEMBL292902 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL291690 | — | IC50 | = | 919.0 | nM | 6.04 |
| CHEMBL418275 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL56174 | — | IC50 | = | 1125.0 | nM | 5.95 |
| CHEMBL60818 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL57048 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL291980 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL60920 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL293307 | — | IC50 | = | 1665.0 | nM | 5.78 |
| CHEMBL57619 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL417223 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL59374 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL61030 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL299679 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL57975 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL418116 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL57866 | — | IC50 | = | 7000.0 | nM | 5.16 |