Assay Detail
Binding
CHEMBL698414
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In vitro binding affinity against rat histamine H3 receptor
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.32 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14638 | CIPROXIFAN | — | 1 | 9.31 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 8.40 |
| CHEMBL88306 | — | — | 1 | 8.15 |
| CHEMBL313803 | — | — | 1 | 7.96 |
| CHEMBL93376 | — | — | 1 | 7.85 |
| CHEMBL330688 | — | — | 1 | 7.85 |
| CHEMBL329116 | — | — | 1 | 7.80 |
| CHEMBL89999 | — | — | 1 | 7.70 |
| CHEMBL89158 | — | — | 1 | 7.57 |
| CHEMBL88746 | — | — | 1 | 7.48 |
| CHEMBL88256 | — | — | 1 | 7.42 |
| CHEMBL314526 | — | — | 1 | 7.25 |
| CHEMBL92541 | — | — | 1 | 6.92 |
| CHEMBL88711 | — | — | 1 | 6.84 |
| CHEMBL91598 | — | — | 1 | 6.78 |
| CHEMBL90821 | — | — | 1 | 6.74 |
| CHEMBL88958 | — | — | 1 | 6.72 |
| CHEMBL91361 | — | — | 1 | 6.70 |
| CHEMBL90968 | — | — | 1 | 6.64 |
| CHEMBL92168 | — | — | 1 | 6.54 |
| CHEMBL328758 | — | — | 1 | 6.24 |
| CHEMBL412673 | — | — | 1 | 6.17 |
| CHEMBL91576 | — | — | 1 | - |
| CHEMBL88419 | — | — | 1 | - |
| CHEMBL328001 | — | — | 1 | - |
| CHEMBL88362 | — | — | 1 | - |
| CHEMBL315904 | — | — | 1 | - |
| CHEMBL92329 | — | — | 1 | - |
| CHEMBL91897 | — | — | 1 | - |
| CHEMBL419133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14638 | CIPROXIFAN | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL88306 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL313803 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL93376 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL330688 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL329116 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL89999 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL89158 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL88746 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL88256 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL314526 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL92541 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL88711 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL91598 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL90821 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL88958 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL91361 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL90968 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL92168 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL328758 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL412673 | — | Ki | = | 674.0 | nM | 6.17 |
| CHEMBL91576 | — | Ki | > | 500.0 | nM | - |
| CHEMBL88419 | — | Ki | > | 500.0 | nM | - |
| CHEMBL328001 | — | Ki | ~ | 400.0 | nM | - |
| CHEMBL88362 | — | Ki | >= | 500.0 | nM | - |
| CHEMBL315904 | — | Ki | > | 500.0 | nM | - |
| CHEMBL92329 | — | Ki | ~ | 500.0 | nM | - |
| CHEMBL91897 | — | Ki | > | 500.0 | nM | - |
| CHEMBL419133 | — | Ki | - | nM | - | |
| CHEMBL91523 | — | Ki | - | nM | - | |
| CHEMBL91427 | — | Ki | > | 500.0 | nM | - |
| CHEMBL330063 | — | Ki | > | 500.0 | nM | - |