Compound Detail
CHEMBL91523
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL91523 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RTVRVPHBXMEZKB-BTJKTKAUSA-N |
| Parent Compound | CHEMBL1179647 |
| Active Moiety | CHEMBL1179647 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
238.4
MW (Da)
3.72
ALogP
2
HBA
1
HBD
37.9
PSA (Ų)
0.60
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 3 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL5076 | Kd | 7.0 | 7.0 | 100.0 | 1 |
| Histamine H2 receptor CHEMBL2882 | Kd | 5.6 | 5.6 | 2511.9 | 1 |
| Histamine H1 receptor CHEMBL3943 | Kd | 4.8 | 4.8 | 15848.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Kd | = | 100.0 | nM | 7.0 | Functional Histamine H3 receptor antagonistic activity in vitro assay on guinea ... | 15115409 |
| Histamine H2 receptor | Kd | = | 2511.89 | nM | 5.6 | Functional H2 receptor antagonistic activity in vitro assay on the isolated spon... | 15115409 |
| Histamine H1 receptor | Kd | = | 15848.93 | nM | 4.8 | Functional Histamine H1 receptor antagonistic activity in vitro assay on guinea ... | 15115409 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15115409 | 10.1021/jm031065q | Histamine H3 receptor | 2 |
| 15115409 | 10.1021/jm031065q | Mus musculus | 1 |
| 15115409 | 10.1021/jm031065q | Histamine H2 receptor | 1 |
| 15115409 | 10.1021/jm031065q | Histamine H1 receptor | 1 |
Data from ChEMBL 36 via Core Engine