Assay Detail
Functional
CHEMBL698435
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Tested for the effective concentration required to inhibit HBV in HepG2.2.15 human liver cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
BMS-200475, a novel carbocyclic 2-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | 8.52 |
| CHEMBL277264 | — | — | 1 | 7.30 |
| CHEMBL27445 | — | — | 1 | 6.89 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.70 |
| CHEMBL25575 | — | — | 1 | 4.98 |
| CHEMBL440792 | — | — | 1 | 4.00 |
| CHEMBL24791 | — | — | 1 | - |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL277264 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL27445 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL25575 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL440792 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL24791 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1540 | PENCICLOVIR | EC50 | >= | 100000.0 | nM | - |