Assay Detail
Functional
CHEMBL699661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay
26
Total Activities
25
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sulfonylurea receptors; K-ATP channels (CHEMBL2095152) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Log EC50 | 19 | - | - |
| EC50 | 7 | 6.11 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138573 | — | — | 1 | 7.17 |
| CHEMBL3392139 | — | — | 2 | 6.61 |
| CHEMBL3392140 | — | — | 1 | 6.26 |
| CHEMBL106033 | — | — | 1 | 6.01 |
| CHEMBL110511 | — | — | 1 | 5.93 |
| CHEMBL108816 | — | — | 1 | 5.63 |
| CHEMBL323460 | — | — | 1 | 5.16 |
| CHEMBL108723 | — | — | 1 | - |
| CHEMBL323787 | — | — | 1 | - |
| CHEMBL108440 | — | — | 1 | - |
| CHEMBL109196 | — | — | 1 | - |
| CHEMBL325339 | — | — | 1 | - |
| CHEMBL109994 | — | — | 1 | - |
| CHEMBL108658 | — | — | 1 | - |
| CHEMBL108251 | — | — | 1 | - |
| CHEMBL322931 | — | — | 1 | - |
| CHEMBL107933 | — | — | 1 | - |
| CHEMBL322507 | — | — | 1 | - |
| CHEMBL321210 | — | — | 1 | - |
| CHEMBL3138579 | — | — | 1 | - |
| CHEMBL320337 | — | — | 1 | - |
| CHEMBL324618 | — | — | 1 | - |
| CHEMBL108400 | — | — | 1 | - |
| CHEMBL111297 | — | — | 1 | - |
| CHEMBL109412 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138573 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL3392139 | — | EC50 | = | 245.47 | nM | 6.61 |
| CHEMBL3392140 | — | EC50 | = | 549.54 | nM | 6.26 |
| CHEMBL106033 | — | EC50 | = | 977.24 | nM | 6.01 |
| CHEMBL110511 | — | EC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL108816 | — | EC50 | = | 2344.23 | nM | 5.63 |
| CHEMBL323460 | — | EC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL109994 | — | Log EC50 | - | — | - | |
| CHEMBL325339 | — | Log EC50 | - | — | - | |
| CHEMBL322931 | — | Log EC50 | - | — | - | |
| CHEMBL108723 | — | Log EC50 | - | — | - | |
| CHEMBL323787 | — | Log EC50 | - | — | - | |
| CHEMBL108440 | — | Log EC50 | - | — | - | |
| CHEMBL109196 | — | Log EC50 | - | — | - | |
| CHEMBL3392139 | — | Log EC50 | - | — | - | |
| CHEMBL108658 | — | Log EC50 | - | — | - | |
| CHEMBL109412 | — | Log EC50 | - | — | - | |
| CHEMBL107933 | — | Log EC50 | - | — | - | |
| CHEMBL322507 | — | Log EC50 | - | — | - | |
| CHEMBL321210 | — | Log EC50 | - | — | - | |
| CHEMBL3138579 | — | Log EC50 | - | — | - | |
| CHEMBL320337 | — | Log EC50 | - | — | - | |
| CHEMBL324618 | — | Log EC50 | - | — | - | |
| CHEMBL108400 | — | Log EC50 | - | — | - | |
| CHEMBL108251 | — | Log EC50 | - | — | - | |
| CHEMBL111297 | — | Log EC50 | - | — | - |