Assay Detail
Binding
CHEMBL699775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound tested for binding affinity towards Ionotropic glutamate receptor kainate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.62 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 7.89 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.40 |
| CHEMBL347581 | — | — | 1 | 4.10 |
| CHEMBL154235 | — | — | 1 | 4.07 |
| CHEMBL30012 | — | — | 1 | - |
| CHEMBL154806 | — | — | 1 | - |
| CHEMBL153945 | — | — | 1 | - |
| CHEMBL154535 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL347581 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL154235 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL30012 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154806 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL153945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154535 | — | IC50 | > | 100000.0 | nM | - |