Assay Detail
Binding
CHEMBL699799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of [3H]AMPA radioligand binding to Ionotropic glutamate receptor AMPA in synaptic plasma membrane prepared from rat forebrain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain/Plasma |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The role of the C-4 side chain of kainate and dihydrokainate in EAA receptor and transporter selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40807 | — | — | 1 | 4.92 |
| CHEMBL19742 | TRANS-CPPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40807 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL19742 | TRANS-CPPA | Ki | = | 106000.0 | nM | - |