Compound Detail
CHEMBL40807
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Basic Information
| ChEMBL ID | CHEMBL40807 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MJUWVAFFSWEHNC-VQVTYTSYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
199.2
MW (Da)
-0.06
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.55
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.92 | 4.92 | 12000.0 | 1 |
| Rattus norvegicus CHEMBL376 | Ki | 4.23 | 4.23 | 59000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate | Ki | = | 10.0 | nM | 8.0 | Compound was tested for the inhibition of [3H]kainate radioligand binding to Ion... | - |
| Glutamate receptor ionotropic, AMPA | Ki | = | 12000.0 | nM | 4.92 | Compound was tested for the inhibition of [3H]AMPA radioligand binding to Ionotr... | - |
| Rattus norvegicus | Ki | = | 59000.0 | nM | 4.23 | Compound was tested for the inhibition of [3H]D-aspartate radioligand uptake int... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate receptor ionotropic, kainate | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Glutamate NMDA receptor | 1 |
| - | 10.1016/S0960-894X(96)00284-3 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine