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Assay Detail

CHEMBL699868

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Functional
Inhibition of calcium influx in jurkat (T cells).
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Expert

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists.
McCalmont WF, Heady TN, Patterson JR, Lindenmuth MA, Haverstick DM, Gray LS, Macdonald TL.
Bioorg Med Chem Lett (2004) 14 : 3691 -3695
PubMed 15203145 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.14 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123213 1 6.00
CHEMBL121392 1 6.00
CHEMBL332864 1 5.70
CHEMBL331873 1 5.52
CHEMBL436172 1 5.52
CHEMBL333416 1 5.52
CHEMBL120731 1 5.52
CHEMBL124112 1 5.52
CHEMBL120982 1 5.52
CHEMBL121443 1 5.30
CHEMBL122842 1 5.16
CHEMBL332876 1 5.16
CHEMBL123063 1 5.10
CHEMBL124287 1 5.00
CHEMBL331997 1 5.00
CHEMBL123044 1 5.00
CHEMBL123718 1 5.00
CHEMBL332875 1 5.00
CHEMBL121695 1 4.82
CHEMBL331421 1 4.82
CHEMBL9330 1 4.70
CHEMBL120447 1 4.60
CHEMBL122893 1 4.52
CHEMBL121221 1 4.52
CHEMBL123879 1 4.00
CHEMBL331233 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123213 IC50 = 1000.0 nM 6.00
CHEMBL121392 IC50 = 1000.0 nM 6.00
CHEMBL332864 IC50 = 2000.0 nM 5.70
CHEMBL331873 IC50 = 3000.0 nM 5.52
CHEMBL436172 IC50 = 3000.0 nM 5.52
CHEMBL333416 IC50 = 3000.0 nM 5.52
CHEMBL120731 IC50 = 3000.0 nM 5.52
CHEMBL124112 IC50 = 3000.0 nM 5.52
CHEMBL120982 IC50 = 3000.0 nM 5.52
CHEMBL121443 IC50 = 5000.0 nM 5.30
CHEMBL122842 IC50 = 7000.0 nM 5.16
CHEMBL332876 IC50 = 7000.0 nM 5.16
CHEMBL123063 IC50 = 8000.0 nM 5.10
CHEMBL124287 IC50 = 10000.0 nM 5.00
CHEMBL331997 IC50 = 10000.0 nM 5.00
CHEMBL123044 IC50 = 10000.0 nM 5.00
CHEMBL123718 IC50 = 10000.0 nM 5.00
CHEMBL332875 IC50 = 10000.0 nM 5.00
CHEMBL121695 IC50 = 15000.0 nM 4.82
CHEMBL331421 IC50 = 15000.0 nM 4.82
CHEMBL9330 IC50 = 20000.0 nM 4.70
CHEMBL120447 IC50 = 25000.0 nM 4.60
CHEMBL122893 IC50 = 30000.0 nM 4.52
CHEMBL121221 IC50 = 30000.0 nM 4.52
CHEMBL123879 IC50 = 100000.0 nM 4.00
CHEMBL331233 IC50 < 1000.0 nM -