Assay Detail
Functional
CHEMBL700433
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The compound was evaluated for the cytotoxicity against human A2780cisR (ovarian) tumor cell lines.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780cisR |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemical synthesis and cytotoxicity of some azinomycin analogues devoid of the 1-azabicyclo[3.1.0]hexane subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.25 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.22 |
| CHEMBL78703 | — | — | 1 | 7.12 |
| CHEMBL312481 | — | — | 1 | 6.81 |
| CHEMBL80331 | — | — | 1 | 6.25 |
| CHEMBL311823 | — | — | 1 | 6.08 |
| CHEMBL78313 | — | — | 1 | 5.96 |
| CHEMBL78644 | — | — | 1 | 5.87 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.52 |
| CHEMBL311864 | — | — | 1 | 5.46 |
| CHEMBL78657 | — | — | 1 | - |
| CHEMBL78645 | — | — | 1 | - |
| CHEMBL78745 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL78703 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL312481 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL80331 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL311823 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL78313 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL78644 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL311864 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL78657 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL78645 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL78745 | — | IC50 | > | 25000.0 | nM | - |