Assay Detail
Functional
CHEMBL700523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Potassium voltage-gated channel subfamily KQT member 2 (CHEMBL2985) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.18 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41078 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41078 | — | EC50 | = | 663.0 | nM | 6.18 |