Assay Detail
Functional
CHEMBL700535
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Binding affinity was measured on jurkat cell membrane using [3H3C] as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of beta-galactosidase: potential immunosuppressive and antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.21 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315970 | — | — | 1 | 7.64 |
| CHEMBL83355 | — | — | 1 | 7.53 |
| CHEMBL313065 | — | — | 1 | 6.91 |
| CHEMBL420602 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315970 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL83355 | — | Ki | = | 29.4 | nM | 7.53 |
| CHEMBL313065 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL420602 | — | Ki | = | 170.0 | nM | 6.77 |