Assay Detail
Functional
CHEMBL700627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of the drug against the cytopathic effect for E-377 strain of herpes simplex virus-1 (HSV-1) in human HFF cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.54 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223205 | — | — | 1 | 7.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 7.40 |
| CHEMBL3142423 | — | — | 1 | 7.22 |
| CHEMBL3142421 | — | — | 1 | 6.30 |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | 6.22 |
| CHEMBL3142422 | — | — | 1 | 5.77 |
| CHEMBL3142425 | — | — | 1 | 5.19 |
| CHEMBL3143951 | — | — | 1 | - |
| CHEMBL3142424 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223205 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3142423 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3142421 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL318153 | EDOXUDINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3142422 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3142425 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3143951 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3142424 | — | EC50 | > | 170000.0 | nM | - |