Assay Detail
Functional
CHEMBL700636
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Concentration of the drug required to reduce the proliferation of human foreskin fibroblast cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.40 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223205 | — | — | 1 | 5.36 |
| CHEMBL3142421 | — | — | 1 | 4.12 |
| CHEMBL3142424 | — | — | 1 | 4.09 |
| CHEMBL3142425 | — | — | 1 | 4.04 |
| CHEMBL3143951 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL3142422 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL3142423 | — | — | 1 | - |
| CHEMBL318153 | EDOXUDINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223205 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3142421 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL3142424 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL3142425 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL3143951 | — | IC50 | > | 250000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 440000.0 | nM | - |
| CHEMBL3142422 | — | IC50 | = | 330000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 168000.0 | nM | - |
| CHEMBL3142423 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL318153 | EDOXUDINE | IC50 | = | 115000.0 | nM | - |