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Assay Detail

CHEMBL700641

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxic activity against HFF cells.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HFF
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines.
Pudlo JS, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB.
J Med Chem (1990) 33 : 1984 -1992
PubMed 2163454 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.35 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62099 1 5.35
CHEMBL61676 1 -
CHEMBL291653 1 -
CHEMBL303055 1 -
CHEMBL294758 1 -
CHEMBL61716 1 -
CHEMBL418640 1 -
CHEMBL59959 1 -
CHEMBL291375 1 -
CHEMBL60024 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62099 IC50 = 4500.0 nM 5.35
CHEMBL61676 IC50 > 100000.0 nM -
CHEMBL291653 IC50 > 100000.0 nM -
CHEMBL303055 IC50 > 100000.0 nM -
CHEMBL294758 IC50 > 100000.0 nM -
CHEMBL61716 IC50 > 100000.0 nM -
CHEMBL418640 IC50 > 100000.0 nM -
CHEMBL59959 IC50 > 100000.0 nM -
CHEMBL291375 IC50 > 100000.0 nM -
CHEMBL60024 IC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR IC50 > 100000.0 nM -