Assay Detail
Binding
CHEMBL701240
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Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA 1 using cell membranes prepared from HEK293 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.78 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299180 | — | — | 1 | 6.16 |
| CHEMBL51660 | — | — | 1 | 5.96 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.87 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.12 |
| CHEMBL51008 | — | — | 1 | - |
| CHEMBL298800 | — | — | 1 | - |
| CHEMBL301536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299180 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL51660 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL275040 | KAINIC ACID | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL51008 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL298800 | — | Ki | = | 113400.0 | nM | - |
| CHEMBL301536 | — | Ki | > | 10000.0 | nM | - |