Assay Detail
Functional
CHEMBL701322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The drug dependent inhibition of LTB4 biosynthesis in human whole blood (HWB) activated with the ionophore A-23187
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.32 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82760 | — | — | 1 | 6.89 |
| CHEMBL38958 | — | — | 1 | 6.89 |
| CHEMBL38545 | — | — | 1 | 6.58 |
| CHEMBL80696 | — | — | 1 | 6.57 |
| CHEMBL289751 | — | — | 1 | 6.57 |
| CHEMBL2114162 | — | — | 1 | 6.55 |
| CHEMBL78938 | — | — | 3 | 6.44 |
| CHEMBL79383 | — | — | 1 | 6.40 |
| CHEMBL39617 | — | — | 1 | 6.39 |
| CHEMBL3350287 | — | — | 1 | 6.33 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 6.30 |
| CHEMBL311968 | — | — | 1 | 6.17 |
| CHEMBL78013 | — | — | 1 | 6.06 |
| CHEMBL433133 | — | — | 1 | 6.01 |
| CHEMBL78854 | — | — | 1 | 5.60 |
| CHEMBL78201 | — | — | 1 | 5.54 |
| CHEMBL310384 | — | — | 1 | - |
| CHEMBL40073 | — | — | 1 | - |
| CHEMBL81904 | — | — | 1 | - |
| CHEMBL78789 | — | — | 1 | - |
| CHEMBL80287 | — | — | 1 | - |
| CHEMBL39473 | — | — | 1 | - |
| CHEMBL80726 | — | — | 1 | - |
| CHEMBL79881 | — | — | 1 | - |
| CHEMBL80802 | — | — | 1 | - |
| CHEMBL80158 | — | — | 1 | - |
| CHEMBL80512 | — | — | 1 | - |
| CHEMBL310276 | — | — | 1 | - |
| CHEMBL310055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82760 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL38958 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL38545 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL80696 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL289751 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL2114162 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL78938 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL79383 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL39617 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3350287 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL311968 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL78938 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL78013 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL433133 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL78854 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL78201 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL80726 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL40073 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL81904 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL78789 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL80287 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL78938 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL39473 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL79881 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL310384 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL80802 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL80158 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL80512 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL310276 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL310055 | — | IC50 | > | 3000.0 | nM | - |