Assay Detail
Binding
CHEMBL701402
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Binding affinity by its ability to displace [3H]-U-69,593 from kappa receptor in homogenates of guinea pig brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans.12.1 A phenethyl analogue of the -selective opioid receptor antagonist cyprodime
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.40 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606644 | — | — | 1 | 8.82 |
| CHEMBL1628270 | CYPRODIME BROMIDE | — | 1 | 7.21 |
| CHEMBL545208 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606644 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL1628270 | CYPRODIME BROMIDE | Ki | = | 61.1 | nM | 7.21 |
| CHEMBL545208 | — | Ki | = | 690.0 | nM | 6.16 |