Assay Detail
Functional
CHEMBL701406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER14 (human EGFR overexpressing) cell proliferation.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.94 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53898 | — | — | 1 | 5.60 |
| CHEMBL55979 | — | — | 1 | 5.46 |
| CHEMBL54471 | — | — | 1 | 5.16 |
| CHEMBL56132 | — | — | 1 | 4.82 |
| CHEMBL291313 | — | — | 1 | 4.70 |
| CHEMBL55204 | — | — | 1 | 4.70 |
| CHEMBL56542 | — | — | 1 | 4.60 |
| CHEMBL56219 | — | — | 1 | 4.46 |
| CHEMBL56879 | — | — | 1 | - |
| CHEMBL56731 | — | — | 1 | - |
| CHEMBL294213 | — | — | 1 | - |
| CHEMBL57462 | — | — | 1 | - |
| CHEMBL55360 | — | — | 1 | - |
| CHEMBL56393 | — | — | 1 | - |
| CHEMBL56964 | — | — | 1 | - |
| CHEMBL293584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53898 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL55979 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL54471 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL56132 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL291313 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL55204 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL56542 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL56219 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL56879 | — | IC50 | < | 20000.0 | nM | - |
| CHEMBL56731 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL294213 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57462 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL55360 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL56393 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL56964 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL293584 | — | IC50 | > | 30000.0 | nM | - |