Assay Detail
Functional
CHEMBL701775
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Concentration required to reduce growth of human jurkat leukemia cells to 50% of control cultures, determined using a 72 hr continuous exposure
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.43 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34843 | — | — | 1 | 6.30 |
| CHEMBL289352 | — | — | 1 | 6.12 |
| CHEMBL35422 | — | — | 1 | 6.12 |
| CHEMBL290443 | — | — | 1 | 6.10 |
| CHEMBL37647 | — | — | 1 | 6.00 |
| CHEMBL37644 | — | — | 1 | 5.85 |
| CHEMBL415467 | — | — | 1 | 5.82 |
| CHEMBL289040 | — | — | 1 | 5.82 |
| CHEMBL9657 | — | — | 1 | 5.70 |
| CHEMBL35072 | — | — | 1 | 5.70 |
| CHEMBL35745 | — | — | 1 | 5.60 |
| CHEMBL37787 | — | — | 1 | 5.60 |
| CHEMBL38217 | — | — | 1 | 5.52 |
| CHEMBL36405 | — | — | 1 | 5.51 |
| CHEMBL35439 | — | — | 1 | 5.40 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 5.40 |
| CHEMBL36404 | — | — | 1 | 5.30 |
| CHEMBL287878 | — | — | 1 | 5.30 |
| CHEMBL37404 | — | — | 1 | 5.22 |
| CHEMBL290441 | — | — | 1 | 5.12 |
| CHEMBL35205 | — | — | 1 | 5.07 |
| CHEMBL37492 | — | — | 1 | 5.00 |
| CHEMBL287889 | o-Amsacrine | — | 1 | 5.00 |
| CHEMBL289684 | — | — | 1 | 4.94 |
| CHEMBL290585 | — | — | 1 | 4.85 |
| CHEMBL288290 | — | — | 1 | 4.82 |
| CHEMBL416958 | — | — | 1 | 4.82 |
| CHEMBL35588 | — | — | 1 | 4.80 |
| CHEMBL37940 | — | — | 1 | 4.70 |
| CHEMBL35917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34843 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL289352 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL35422 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL290443 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL37647 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL37644 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL415467 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL289040 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL9657 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL35072 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL35745 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL37787 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL38217 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL36405 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL35439 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL36404 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL287878 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL37404 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL290441 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL35205 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL37492 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL287889 | o-Amsacrine | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL289684 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL290585 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL288290 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL416958 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL35588 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL37940 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL290767 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL290766 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL36532 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL9806 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL38374 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL34930 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL34941 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL43 | AMSACRINE | IC50 | < | 1000.0 | nM | - |
| CHEMBL36828 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL34804 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL37615 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL34598 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL35917 | — | IC50 | > | 20000.0 | nM | - |