Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL701776

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibitory activity against human Jurkat leukemia cell line (JLC)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Intermediate

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.
Deady LW, Rodemann T, Zhuang L, Baguley BC, Denny WA.
J Med Chem (2003) 46 : 1049 -1054
PubMed 12620081 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.44 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL9902 1 9.00
CHEMBL65 CAMPTOTHECIN -1.0 1 8.25
CHEMBL9676 1 8.17
CHEMBL9595 1 8.07
CHEMBL268798 1 8.03
CHEMBL53463 DOXORUBICIN 4.0 1 8.02
CHEMBL269663 1 7.58
CHEMBL9489 1 7.29
CHEMBL266809 1 6.91
CHEMBL44657 ETOPOSIDE 4.0 1 6.80
CHEMBL276261 1 6.37
CHEMBL9940 1 6.24
CHEMBL611408 1 5.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL9902 IC50 = 1.0 nM 9.00
CHEMBL65 CAMPTOTHECIN IC50 = 5.6 nM 8.25
CHEMBL9676 IC50 = 6.7 nM 8.17
CHEMBL9595 IC50 = 8.5 nM 8.07
CHEMBL268798 IC50 = 9.4 nM 8.03
CHEMBL53463 DOXORUBICIN IC50 = 9.6 nM 8.02
CHEMBL269663 IC50 = 26.0 nM 7.58
CHEMBL9489 IC50 = 51.0 nM 7.29
CHEMBL266809 IC50 = 123.0 nM 6.91
CHEMBL44657 ETOPOSIDE IC50 = 160.0 nM 6.80
CHEMBL276261 IC50 = 424.0 nM 6.37
CHEMBL9940 IC50 = 580.0 nM 6.24
CHEMBL611408 IC50 = 1070.0 nM 5.97