Assay Detail
Binding
CHEMBL701841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]AMPA binding to Ionotropic glutamate receptor from rat whole brain.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
8-(1H-imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-alpha]quinoxalinone and related compounds: synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294781 | — | — | 1 | 7.70 |
| CHEMBL64772 | — | — | 1 | 7.68 |
| CHEMBL303068 | — | — | 1 | 7.32 |
| CHEMBL302672 | — | — | 1 | 7.24 |
| CHEMBL294308 | — | — | 1 | 7.18 |
| CHEMBL13260 | YM-90K | — | 1 | 7.08 |
| CHEMBL292806 | — | — | 1 | 7.02 |
| CHEMBL63656 | — | — | 1 | 6.89 |
| CHEMBL27653 | — | — | 1 | 6.85 |
| CHEMBL63108 | — | — | 1 | 6.82 |
| CHEMBL64044 | — | — | 1 | 6.72 |
| CHEMBL62842 | — | — | 1 | 6.72 |
| CHEMBL62431 | — | — | 1 | 6.70 |
| CHEMBL64870 | — | — | 1 | 6.48 |
| CHEMBL294540 | — | — | 1 | 6.41 |
| CHEMBL408393 | — | — | 1 | 6.36 |
| CHEMBL64133 | — | — | 1 | 5.35 |
| CHEMBL63326 | — | — | 1 | 5.18 |
| CHEMBL294801 | — | — | 1 | - |
| CHEMBL64888 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294781 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL64772 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL303068 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL302672 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL294308 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL13260 | YM-90K | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL292806 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL63656 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL27653 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL63108 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL64044 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL62842 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL62431 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL64870 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL294540 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL408393 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL64133 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL63326 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL294801 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL64888 | — | Ki | > | 10000.0 | nM | - |