Compound Detail
CHEMBL294308
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Basic Information
| ChEMBL ID | CHEMBL294308 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZPSHBDBNFJISFL-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
319.2
MW (Da)
2.79
ALogP
6
HBA
1
HBD
68.2
PSA (Ų)
0.59
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.5
Ki 1 meas. best 7.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 7.18 | 7.18 | 66.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 66.0 | nM | 7.18 | Inhibition of [3H]AMPA binding to Ionotropic glutamate receptor from rat whole b... | 9207947 |
| Rattus norvegicus | IC50 | = | 320.0 | nM | 6.5 | The compound was tested for anti-KA-Induced Neurotoxicity in rat primary hippoca... | 9207947 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9207947 | 10.1021/jm960664c | Glutamate NMDA receptor | 2 |
| 9207947 | 10.1021/jm960664c | Glutamate receptor ionotropic, AMPA | 1 |
| 9207947 | 10.1021/jm960664c | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine