Assay Detail
Functional
CHEMBL798076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for anti-KA-Induced Neurotoxicity in rat primary hippocampal cultures.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
8-(1H-imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-alpha]quinoxalinone and related compounds: synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.38 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302672 | — | — | 1 | 6.52 |
| CHEMBL294308 | — | — | 1 | 6.50 |
| CHEMBL222519 | NBQX | — | 1 | 6.42 |
| CHEMBL13260 | YM-90K | — | 1 | 6.09 |
| CHEMBL294781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302672 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL294308 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL222519 | NBQX | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL13260 | YM-90K | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL294781 | — | IC50 | = | - | nM | - |