Compound Detail
CHEMBL27653
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Basic Information
| ChEMBL ID | CHEMBL27653 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCEDPPPKQBHDND-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
274.2
MW (Da)
0.53
ALogP
9
HBA
2
HBD
140.1
PSA (Ų)
0.51
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 6.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 6.85 | 6.85 | 140.0 | 2 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | Ki | 6.85 | 5.925 | 140.0 | 2 |
| Glutamate receptor-interacting protein 1 CHEMBL2366484 | Ki | 6.85 | 6.85 | 140.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 140.0 | nM | 6.85 | Inhibition of [3H]AMPA binding to Ionotropic glutamate receptor from rat whole b... | 9207947 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 140.0 | nM | 6.85 | In vitro inhibition of the specific binding of [3H]AMPA to Ionotropic glutamate ... | 8632440 |
| Glutamate receptor-interacting protein 1 | Ki | = | 140.0 | nM | 6.85 | Inhibition of AMPA binding to Rattus norvegicus (rat) whole brain AMPA receptor | - |
| Glutamate receptor ionotropic AMPA | Ki | = | 140.0 | nM | 6.85 | Displacement of [3H]AMPA from AMPA receptor (unknown origin) | 34998058 |
| Glutamate receptor ionotropic AMPA | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]glycine from AMPA receptor (unknown origin) | 34998058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic AMPA | 2 |
| 9207947 | 10.1021/jm960664c | Glutamate receptor ionotropic, AMPA | 1 |
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, AMPA | 1 |
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, NMDA 1 | 1 |
| - | 10.1007/s00044-012-9972-6 | Mus musculus | 1 |
| - | 10.1007/s00044-012-9972-6 | Glutamate receptor-interacting protein 1 | 1 |
Data from ChEMBL 36 via Core Engine