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Assay Detail

CHEMBL702286

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against growth of JURKAT cells after 144h.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Intermediate

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Bergeron RJ, Weimar WR, Müller R, Zimmerman CO, McCosar BH, Yao H, Smith RE.
J Med Chem (1998) 41 : 3901 -3908
PubMed 9748365 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.43 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL77101 DIETHYLHOMOSPERMINE 1.0 1 6.70
CHEMBL34476 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL77101 DIETHYLHOMOSPERMINE IC50 = 200.0 nM 6.70
CHEMBL34476 IC50 = 70000.0 nM 4.16