Assay Detail

CHEMBL702287

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Functional

inhibitory activity against growth of JURKAT cells after 144h.

ChEMBL ↗

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Target

Jurkat (CHEMBL397) ↗

Open DB target context

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Primary target Jurkat

CHEMBL397

Anchored from Assay target.

Protein identity Jurkat

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Jurkat
Confidence	1 — Organism
Curated By	Intermediate

Target

Jurkat (CHEMBL397) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Effect of polyamine analogues on hypusine content in JURKAT T-cells.

Bergeron RJ, Weimar WR, Müller R, Zimmerman CO, McCosar BH, Yao H, Smith RE.
J Med Chem (1998) 41 : 3901 -3908
PubMed 9748365 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.06	6.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL44083	BIS(ETHYL)NORSPERMINE	—	1	6.19
CHEMBL35633	—	—	1	5.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL44083	BIS(ETHYL)NORSPERMINE	IC50	=	650.0	nM	6.19
CHEMBL35633	—	IC50	=	1200.0	nM	5.92