Assay Detail
Functional
CHEMBL702307
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The compound was tested in vitro for inhibition of IL-2 release stimulated with PMA/ionomycin by Jurkat cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.50 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.92 |
| CHEMBL216520 | — | — | 1 | 7.70 |
| CHEMBL2370707 | — | — | 1 | 7.68 |
| CHEMBL2370706 | — | — | 1 | 7.21 |
| CHEMBL2370711 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL216520 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2370707 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2370706 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2370711 | — | IC50 | = | 107.0 | nM | 6.97 |