Assay Detail
Functional
CHEMBL702312
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Binding affinity was measured on jurkat cell membrane using [3H3C] as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of beta-galactosidase: potential immunosuppressive and antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.05 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85752 | — | — | 1 | 8.96 |
| CHEMBL87871 | — | — | 1 | 8.32 |
| CHEMBL84597 | — | — | 1 | 7.82 |
| CHEMBL87691 | — | — | 1 | 7.06 |
| CHEMBL83076 | — | — | 1 | 6.52 |
| CHEMBL315281 | — | — | 1 | 6.52 |
| CHEMBL313539 | — | — | 1 | 6.50 |
| CHEMBL86462 | — | — | 1 | 6.34 |
| CHEMBL314031 | — | — | 1 | 6.25 |
| CHEMBL82795 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85752 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL87871 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL84597 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL87691 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL83076 | — | Ki | = | 301.0 | nM | 6.52 |
| CHEMBL315281 | — | Ki | = | 305.0 | nM | 6.52 |
| CHEMBL313539 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL86462 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL314031 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL82795 | — | Ki | = | 697.0 | nM | 6.16 |