Assay Detail
Functional
CHEMBL702375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of Jurkat cell proliferation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.27 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552873 | — | — | 1 | 7.16 |
| CHEMBL554551 | — | — | 1 | 6.10 |
| CHEMBL282988 | — | — | 1 | 5.66 |
| CHEMBL300580 | — | — | 1 | 5.52 |
| CHEMBL3216873 | — | — | 1 | 4.70 |
| CHEMBL554203 | — | — | 1 | 4.60 |
| CHEMBL553022 | — | — | 1 | 4.30 |
| CHEMBL554057 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552873 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL554551 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL282988 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL300580 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3216873 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL554203 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL553022 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL554057 | — | IC50 | = | 80000.0 | nM | 4.10 |