Assay Detail
Functional
CHEMBL702376
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In vitro growth factor-independent proliferation against human leukemia T cell line jurkat was determined
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro cytotoxicity of diastereoisomerically modified dolastatin 15 analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.62 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35769 | DOLASTATIN 15 | — | 1 | 8.30 |
| CHEMBL3350145 | — | — | 2 | 8.00 |
| CHEMBL3350146 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35769 | DOLASTATIN 15 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3350145 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3350145 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3350146 | — | IC50 | = | 700.0 | nM | 6.16 |